| | Runs | playerId | seasonId | clubId | matchId | Runs | Player | Team | Season | Grade | Round | Inns | Opponent |
| 1 | 171 | 333399 | 155 | 14386 | 4019243 | 171* | Darren Anderson | Knox Churches | 2021/2022 | McCarthy Shield (LOC1) | 8 | 1 | Hartley |
| 2 | 84 | 333399 | 155 | 14386 | 4019233 | 84* | Darren Anderson | Knox Churches | 2021/2022 | McCarthy Shield (LOC1) | 5 | 1 | Melbourne Sixers SC |
| 3 | 77 | 333399 | 155 | 14386 | 4019261 | 77 | Darren Anderson | Knox Churches | 2021/2022 | McCarthy Shield (LOC1) | 12 | 1 | Deepdene Uniting |
| 4 | 75 | 411125 | 155 | 14386 | 4019217 | 75 | Preshith Ganegoda | Knox Churches | 2021/2022 | McCarthy Shield (LOC1) | 1 | 1 | Deepdene Uniting |
| 5 | 64 | 399702 | 155 | 14386 | 4018760 | 64* | Shane de Kretser | Knox Churches | 2021/2022 | LOC 8 - 35 overs (Carr Sheild) | 7 | 1 | AYC Harlequins |
| 6 | 62 | 411125 | 155 | 14386 | 4019241 | 62 | Preshith Ganegoda | Knox Churches | 2021/2022 | McCarthy Shield (LOC1) | 7 | 1 | Victorian Cavaliers |
| 7 | 59 | 411125 | 155 | 14386 | 4019252 | 59 | Preshith Ganegoda | Knox Churches | 2021/2022 | McCarthy Shield (LOC1) | 10 | 1 | Melbourne Sixers SC |
| 8 | 56 | 399702 | 155 | 14386 | 4019270 | 56 | Shane de Kretser | Knox Churches | 2021/2022 | McCarthy Shield (LOC1) | 14 | 1 | Victorian Cavaliers |
| 9 | 53 | 389664 | 155 | 14386 | 4018776 | 53* | Leon Lewis | Knox Churches | 2021/2022 | LOC 8 - 35 overs (Carr Sheild) | 10 | 1 | STC South Camberwell |
| 10 | 53 | 2268894 | 155 | 14386 | 4018782 | 53* | Dirk D'Silva | Knox Churches | 2021/2022 | LOC 8 - 35 overs (Carr Sheild) | 11 | 1 | Malvern Valley |
| 11 | 53 | 399702 | 155 | 14386 | 4018766 | 53* | Shane de Kretser | Knox Churches | 2021/2022 | LOC 8 - 35 overs (Carr Sheild) | 8 | 1 | Glen Waverley (Sunday) |
| 12 | 52 | 333367 | 155 | 14386 | 4019217 | 52 | Michael de Kretser | Knox Churches | 2021/2022 | McCarthy Shield (LOC1) | 1 | 1 | Deepdene Uniting |
| 13 | 52 | 684146 | 155 | 14386 | 4018789 | 52* | Nicholas Mawson | Knox Churches | 2021/2022 | LOC 8 - 35 overs (Carr Sheild) | 13 | 1 | West Ivanhoe United |
| 14 | 51 | 2304049 | 155 | 14386 | 4018782 | 51* | Prashant Rania | Knox Churches | 2021/2022 | LOC 8 - 35 overs (Carr Sheild) | 11 | 1 | Malvern Valley |
| 15 | 50 | 2304049 | 155 | 14386 | 4018756 | 50* | Prashant Rania | Knox Churches | 2021/2022 | LOC 8 - 35 overs (Carr Sheild) | 6 | 1 | Richmond Union |
| 16 | 50 | 623129 | 155 | 14386 | 4018766 | 50* | James Bristow | Knox Churches | 2021/2022 | LOC 8 - 35 overs (Carr Sheild) | 8 | 1 | Glen Waverley (Sunday) |
Note: Qualification levels for this report are 50 and 100 runs.
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